• Autoimmune diseases affecting the gut, skin, and joints are on the rise.
• As we learn new things about inflammatory pathway, we can choose certain drugs that target specific points in the pathway.
• The ultimate goal is mucosal/ histologic healing, not just endoscopic- so need to rescope to see effect of therapy.
• JAK-STAT pathway stimulates the transcription of cytokines.
• JAK inhibitors are useful for IBD but also eczema, psoriatic arthritis, rheumatoid arthritis, and ankylosing spondylitis.
• JAK data is very impressive for the effectiveness in IBD as shown in several clinical trials.
• In the US, JAK is approved for 2nd line therapy once failure of another agent.
• DVT risk in JAKs really in RA patients that are obese, on MTX, and having 1 cardiac risk factors- so not really in IBD patients.
• JAKs do have potential risk for skin cancer, other malignancy, infection.
• The most common adverse effects for JAKs are shingles and acne.
• Do not use JAKs in pregnancy or in women who plan to become pregnant.
Also, here is a link to the recorded program we can include for those who still want to participate and get the CME credit. CLICK HERE FOR CME PRESENTATION
If you attended last Thursday or have watched from the link above, what were your thoughts? Comment below…
&media=https://scgastroassn.com/wp-content/uploads/2024/08/Blog2.jpg){kind=link}
Thank you very much Chris for your review.
It is my understanding that those with IBD are at increased risk for thromboembolism with or without JAKS. Like to know the experience of others.
Is anybody familiar with autoimmune protocol diets the new Internet craze for autoimmune disorders?
Hey Lou! I think that is correct- I think it is just that JAK’s do not add any additional DVT risk on top the underlying IBD. I don’t know anything about autoimmune protocol diets except that some patients are really into it.